【摘要】 肺血管对急性缺氧的反应性在大鼠种系间存在明显差异,并可能与组胺调节缺氧性肺血管反应的差别有关。急性缺氧时Hilltop和Wistar大鼠肺血管阻力分别增加174.09±13.28和122.45±15.27mN·s·cm^-5（±SE）。静注扑尔敏和甲氰咪胍后,Wistar大鼠肺血管反应增强,Hilltop大鼠肺血管反应无明显改变。更多还原

【Abstract】 There is a difference in pulmonary vascular reactivity to acute hypoxia in strains of rats, which may be partly related to the different role of histamine in modulating hypoxic pulmonary vasoconstriction. During acute hypoxia the increments of pulmonary vascular resistance in Hilltop and in Wistar rats were 174.09 ± 13.28 and 122.45 ± 15.27 mN·s·cm-5 respectively (X±SE, P<0.05). After chlor-pheniramine and cimetidine were used, the reactivity of the pulmonary vasculaiure to acute hypoxia increased in Wistar rats, while no significant change was seen inHilltop rats.更多还原