【摘要】 1,6-二磷酸果糖(FDP)为对多种代谢径路有调节作用的高能底物,已应用于休克、缺氧等的治疗。肺心病呼吸衰竭应用常规治疗加FDP(5g/日)9例,2周后外围血淋巴细胞(PBL)内Ca含量显著高于应用前和常规治疗组。用10～15kg全麻开胸健康雄犬10条,隔2h先后静注FDP(250mg/kg)和FDP+异搏停(V;0.1mg/kg)。FDP注射后15、30、45分,左室心肌和PBL平均细胞内Ca含量分别较药前增高144—293％和231—259％(P<0.01),血清Ca含量均低于药前(P<0.01)。注射FDP+V后则细胞内及血清Ca含量均未见与药前有显著差异。所见提示FDP促使细胞内钙含量增高和细胞外含量降低的效应,可能在于药物作用于慢通道而增强Ca内流所致。更多还原

【Abstract】 Fructose-1, 6-diphosphate(FDP), the high-energy substrate effective in regulating many intracellular metabolic pathways, has been proved benefic- ial in the treatment of shock and ischemic conditions. In 9 cases of chronic cor pulmonale with acute pulmonary failure managed with routine therapeutic measures and FDP(5g/d) for 2 weeks, the intralymphocytic Ca contents were significantly higher than those before FDP administration and those of 30 trsated controls. In studying its effects on celluar calcium, 250 mg FDP(n=10) and FDP with 0.1mg verapamil (FDP+V) two hours later (n=7) per kg body weight were administered intravenously to anesthetized chestopened 10 to 15kg male dogs and pre- and serial post-treatment atomic absorption spectometric measurement on PBL and left ventricual cardiomyocyte and raised 15, 30 and 45 minutes following FDP injection, increased by 144％ to 293％ in cardiomyocytes and by 231％ to 259％ in PBLs and serum Ca lowered as compared with the pretreatment values(p<.01). No significant changes we- re revealed in corresponding measurements FDP+V. These results might Sug- gest that FDP may cause elevation in cell Ca and reduction in its extracellular levels and that FDP may effect by actions on slow Ca channel leading to en- hanced Ca iuflux.更多还原