【摘要】 用组胺H₂受体拮抗剂（甲氰咪胍或呋喃硝胺）处理正常和亚致死量γ-射线照射小鼠,探讨正常体内造血和再生骨髓中造血重建与组胺受体的关系。发现非毒性剂量的甲氰咪胍对正常小鼠骨髓多能造血干细胞（CFU-s）无抑制作用,但可抑制小鼠体内粒单系祖细胞（CFU-GM）的生长和亚致死量照射后CFU-s产率的恢复。组胺可能与骨髓的再生有关,组胺H₂受体拮抗剂可抑制骨髓的造血重建。更多还原

【Abstract】 The effects of histamine H₂-receptor antagonists（cimetidine and ranitidine）on bone marrow hematopoiesis of normal and sublethally irradiated mice wereinvestigated.It was found that non-toxic dosage of cimetidine had no significanteffect on CFU-s of the normal mouse,but it inhibited CFU-GM growth with a do-sage-dependent relationship and the recovery of CFU-s formation from sublethalγ-ray irradiation.These results suggest that histamine may play a role in bonemarrow regeneration after sublethal irradiation.Histamine H₂receptor antag-onists can inhibit hemopoietic reconstruction in regenerating bone marrow.更多还原