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冬虫夏草免疫增强作用机理的研究

STUDIES ON EFFECTS OF CORDYCEP SINENSIS (BERK) SACC ON LYMPHOCYTE FUNCTIONS

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【作者】 匡彦德王美英钱琴芳谢家骏曹蓓莉关惠贞吴耀晴

【Author】 Kuang Yande Wang Meiying Qian Qinfang Xie YiajunCao Beili Guan Huizhen Wu YaojingDepartment of Immunology, Shanghai Medical University,Shanghai Chinese Drug Research Institute

【机构】 上海医科大学基础医学部免疫学教研室上海中药研究所上海医科大学基础医学部免疫学教研室

【摘要】 冬虫夏草水提取液对小鼠胸腺细胞、脾细胞以及脾细胞经除去thy-1+细胞后残存的细胞都有与剂量相关的致有丝分裂作用,说明虫草对T和B淋巴细胞的增殖有作用。虫草与脾细胞共育24小时的上清液中不能检出或仅能检出极低IL2活性,但虫草活化的脾细胞表达与ConA活化的脾细胞相近数量的IL2受体。

【Abstract】 The mitogenic effects of Gordyceps Sinensis (Berk) Sacc (CSS) on murine thymo-cytes, spleen cells and the residual splenocytes after treating with anti-thy-1 antibody and complement were observed. CSS had a dose related mitogenic effects on all of those cells. The results indicated that OSS had mitogenic effects on T and B lymphocytes. We couldn’t detect or only detected very low interleukin 2 (IL 2) activity in the supernatant of spleen Cell cultured with CSS for 24 hours, but CSS-activated splenocytes were able to absorb IL 2 activity from culture medium.

【基金】 国家然科学基金
  • 【被引频次】77
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