【摘要】 本实验比较了支配上呼吸道肌的舌下神经和喉返神经放电与支配吸气肌的膈神经放电的异同,并观察了这三种神经对肺牵张感受器传入冲动和喉上神经传入冲动的异同。结果表明:1、舌下神经和喉返神经放电早于膈神经;2、舌下神经和喉返神经均可被肺牵张传入冲动所抑制,尤以舌下神经为最;3、刺激喉上神经在膈神经、舌下神经和喉返神经上引起的反应相似。上述结果提示:1、膈神经、舌下神经和喉返神经在脑干中通过的神经环路不同,通过的神经元数目不同;2、肺牵张感受器和喉上神经传入冲动是通过改变舌下神经和喉返神经的放电类型而影响呼吸道的开闭。更多还原

【Abstract】 Recently,the pathogenesis of upper airwar occlusion duringsleep was noticed by many investigators.The target of this work is tocompare the difference of the whole phrenic nerve(PHR),hypoglossalnerve(HYP)and recurrent laryngeal nerve(RL)discharges,to observethe responses of those three nerves to pulmonary stretch receptor(PSR)and superior laryngeal nerve(SL)inputs.The experiments were done ondecerebrate,paralyzed cats ventilated with a cycle triggered pump.Thedischarge pattern of the PHR,HYP and RL in different conditions weredifferent in several ways:a)HYP and RL had earlier onsets,40～48 msbefore PHR;b)PHR had a augmenting pattern within the whold inspira-tion phase;HYP had a decrementing pattern within the whole inspirationphase;RL had a plateau - like pattern breaking down at the end of ins-piration within the both inspiration and expiration phases;c)Wheninflations were withheld,resulting in elimination of phasic PSR input,there was an increase in HYP and RL activity,and both dischargepatterns became augmenting,but no significant change of pattern in PHRactivity;d)SL stimulation at inspiration elicited an excitatory responsefollowed by a suppression of activity in the ipsilateral HYP and RL,andin the contralateral PHR,but they had different latencies of excitation.Our results indicate:a)HYP and RL had earlier onsets than PHR;b)HYP and RL discharges are inhibited by PSR inputs,with the HYPmore strongly inhibited;c)SL afferents exert similar effects on the PHR,HYP,and RL.These different effects suggest that a)there are differentneural populations driving the PHR,HYP,and RL in brain stem;b)Both PSR and SL afferents affect upper airway patency by changing HYPand RL discharges.更多还原