【摘要】 本文用光镜和电镜观察了4例Gilbert综合征(GS)组织病理学改变。光镜显示病变很轻,仅有肝细胞的疏松变性及点状坏死;电镜显示滑面内质网明显增多,核形不规则,毛细胆管扩张,微绒毛减少。文中对GS血清中非结合胆红素排泌困难的机制进行了讨论,认为除归因于葡萄糖醛酸移换酶缺乏外,与胆红素摄取障碍也有关系。更多还原

【Abstract】 The clinical and histological changes of Gilbert’s syndrome are observed in4 cases by microscopy and electron microscopy. The microscopy only shows histo-logical changes of loose degeneration and focal necrosis. The electron microsco-py shows that the smooth endoplasmic reticulum is markedly increased and thenuclear pattern is irregular. The bile canaliculus is obviously enlarged and themicrovilli are decreased. The study suggests that the difficulty in the excretionof bilirubin is not only associated with the lack of glucuronyl transferase butwith the bilirubin uptake impairment.更多还原