【摘要】 采用体外实验研究外周T₄转变为T₃的脱单碘作用和能调节此过程的药物。T₄转变为T₃时,T₄的km值为7.77μM,Vmax为每分钟1.33pmol/mg蛋白质。心得安、心得舒、美多心安、肾上腺素、去甲肾上腺素、异丙肾上腺素、育红宾、丙基硫氧嘧啶和甲基硫氧嘧啶均能抑制该酶活性,且与剂量有关,而cAMP、他巴唑无抑制作用。更多还原

【Abstract】 An in vitro model was used to study peripheral monodeiodination of thryoxine to triiodothyronine（T₃）and the grugs capable of modulating it.The enzyme gave a K_m of 7.77 μm for T₄,and a V_max of 1.33 pmol/min per mgofprotein.Propranolol,alprenolol,metopralol,epinephrine,norepinephrine,isoproterenol and yohimbine,propylthiouracil and methylthiouracil inhibited the enzyme in a dosedependent manner,cAMP and methimazole did not inhibit the enzyme.更多还原