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脑血管病患者血浆TXB2、6-酮PGF1α和β-TG同步监测的临床应用

THE CLINICAL APPLICATION OF MEASUREMENTS OF PLASMA TXB2, 6-Keto-PGF1α AND β-TG SIMULTANEOUSLY IN PATIENTS WITH CEREBROVASCULAR DISEASES

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【摘要】 用放兔法同步检测急性脑血管病患者(ACVDs)95例血浆β-TG、TXB2和6-酮PGF1α(下简称6-酮)的含量变化。发现ACVDs血浆β-TG、TXB2含量增高,而6-酮均降低,与对照组相比有显著差异,并可作为出血性脑血管病(HCVD)和缺血性脑血管病(ICVD)鉴别指标之一。动态观察还发现阿斯匹林(ASA)对降低ICVD的血浆β-TG和TXB2浓度及改善临床症状、预防缺血性卒中复发有一定价值,而对6-酮则无明显影响。

【Abstract】 The levels of plasma β-TG, TXB2 and 6-Keto-PGF1α were detected simultaneouslyin 95 patients with acute cerebrovascular diseases (ACVDs) by radioimmunoassay. Itwas found that both the plasma β-TG and TXB2 levels in ACVD5 increased and 6-Keto-PGF1α decreased. The difference was very significant when compared with thecontrol group. And the levels of TXB2 and β-TG could be used as an index indifferentiation between haemorrhagic cerebrovascular diseases (HCVD) and ischemiccerebrovascular diseases (ICVD). It was also found that ASA had a better effect indecreasing plasma β-TG and TXB2levels in ICVD, improving clinical manifestations andpreventing the recurrence of ICVD, and no significant influence to 6-Keto-PGF1α.

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