【摘要】 应用大鼠急性心肌梗塞模型观察山莨菪碱(Anisodamine,654-2)对缺血心肌舒张功能的保护作用。实验表明,在体心脏结扎左冠状动脉后,左室舒张功能指标有明显改变,-dp/dtmax降低,LVDEP增高,T值延长,显示心脏舒张功能遭受严重损害。但预先注射654-2的大鼠,上述指标改变明显减小,提示654-2对缺血心肌舒张功能具有一定的保护作用。更多还原

【Abstract】 Effects of anisodamine （654-2） during acute myocardial ischemial were investigated in20 anesthetized open-chest rats, The animals were randomly divided into 2 groups.Normal saline iv 0.5 ml/kg （control group） and 654-2 iv 5mg/kg （treated group） weregiven 15 min before coronary occlusion. In n（?）n-ligated rats all hemodynamic parameterswere decreased significantly after iv 654-2. No change occluded in the control. It wasshown that 654-2 possessed the effects of inhibiting heart vessels. The occlusion of LADcaused a marked change in -dp/dt_max, LVEDP and T (time constant of isovolumic pressure fallsubsequent to -dp/dt_max 20 min after ligation in the control, -dp/dt_max decreased from 525±118to 336±114 kPa, LVEDP increased from -0.35±0.24 to 0.31±0.48 kPa and T increased from8.1±1.9 to 13.0±2.5ms, respectively. But changes were slighter less 525±132 kPa, LVEDPincreased from -0.37 0.33 to -0.16±0.11 kPa and T increased from 4.2±1.7 to 4.5±0.9ms.The degree of reduction on other parameters in treated group was less than that of thecontrol. The results suggest that anisodamine might have exerted protective effect on leftventricular diastolic function during myocardial ischemia.更多还原