【摘要】 用⁵¹Cr释放法和细胞病变抑制法测定AA患者外周血NK细胞活性和PHA诱生IFN_γ水平,结果表明15例AA未缓解期患者NK活性明显低于正常组,8例缓解期患者NK活性有明显增高,但测定29例AA患者外周血PHA诱生IFN_γ水平与正常组差异不大。同时测定二项指标有18例,结果与上述基本一致。二者之间无明显相关关系。文中讨论了AA患者存在免疫失调。更多还原

【Abstract】 Using 51 Cr release assay, we determined NK activity of PBL from 23 cases with AA and 30 normal persons. The NK activity of cases in unremittent stage was significantly lower than that of normal persons (P<0.001). However, it was found that the NK activity of cases in remittent stage was higher than that of cases in unremittent stage (P<0.001). The PHA induced IFN-γ level of 29 cases of AA and 20 normal subjects was also studied by means of the CPE inhibition method, but there was no difference (P>0.1). In 10 of 29 patients with AA, IFN-y induced level was>128 U/ml. The NK activity and IFN-y induction-capacity of PBL were determined in 18 cases with AA, The results were similar. There was no correlation between NK activity and induced IFN-γ levels. Low NK activity and normal or high induced IFN-γ level in AA patients suggests immunologic abnormality of a feedback regulation mechanism. It seems to be useful and significant to determine the NK activity and induced IFN-γ level of PBL in patients with AA.更多还原