【摘要】 本文用多种单克隆抗体对32例慢性肝炎患者的细胞免疫状况进行了研究。结果发现患者肝组织内淋巴细胞和单核、巨噬细胞浸润明显增加,坏死区浸润细胞主要是T₃⁺和T₈⁺细胞。B淋巴细胞浸润极少,浸润淋巴细胞表面IL—2受体阳性细胞与外周血淋巴细胞表面IL—2受体阳性细胞率均无改变。患者外周血单个核细胞改变为T₃⁺下降,T₄/T₈比例下降,单核、巨噬细胞、B淋巴细胞及淋巴细胞表面HLA—DR、DP、DQ标志与正常人无差异。更多还原

【Abstract】 Cellular immunity of 32 cases of chronic hepatitis B was investigated with monoclonal anti-lyphocyte antibodies. The results showed that the infiltration of lymphocytes and monocytes and macrophages in liver tissue from chronic hepatitis B patients increased apparently and that of piecemeal necrosis region was related mainly to T3, T8 positive cells, however there was only a few B+ lyphocytes in the region. There was do difference of percentages of infiltrating lymphocytes with IL-2 receptor between patients and normal control. The results for the determination of PBL from the patients showed that the percentage of T3+ cells decreased and so did the value of T4/T8.No changes of mo-nonnuclear, macrophages, B lymphocytes with HLA-DR, DP, DQ marker between the patients and normal control occured.更多还原