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用反渗透法浓缩一磷酸腺苷(AMP)洗脱液

Concentration of Adenosine Monophosphate(AMP)Eluate by Reverse Osmosis

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【作者】 陈联楷; 苑学竞; 郭群晖;

【Author】 Chen Liankai Yuan Xuejing Guo QunHui (Institute of Guangzhou chemistry,Academia Sinica)

【机构】 中国科学院广州化学研究所; 中国科学院广州化学研究所;

【摘要】 在AMP生产过程中,从离子交换树脂洗脱出来的AMP 稀溶液可以用反渗透法浓缩。一次浓缩除去3/4水,浓缩收率在99%以上。如用多次浓缩,将AMP 浓度为0.3mg/ml 的洗脱液浓缩至33.0mg/ml(浓缩100倍!)即达到其结晶沉淀浓度时,浓缩收率达98%。浓缩产品质量符合要求。在累积300多小时的运行试验中,AMP 洗脱液对膜的污染不大,膜透水量下降不严重。此外,本文还考察了AMP 溶液浓度,pH 值以及操作压力的变化对膜性能的影响。

【Abstract】 In the process of AMP production the dilute AMP solution elutedfrom ion-exchange resin column can be concentrated by reverse osmo-sis.Three-fourths of water can be removed by once concentration.And its concentrated recovery is more than 99%.By the way of mul-tiple stage concentration,when the dilute AMP solution of 0.3mg/mlis concentrated to 33.0mg/ml (concentrated to about 100times),thatis,when the solution reaches crystalline concentration,its concen-trated recovery is 98%. The quality of AMP obtained accord with thedemands.Under the test of 300 hours operation the fouling of the membraneresulting from the eluted AMP solution is small.The decrease of fluxis not serious.The effects of AMP solution concentration,pH andoperation pressure on performance of the membrane were also investi-gated in this paper.

  • 【文献出处】 膜科学与技术 ,Membrane Science and Technology , 编辑部邮箱 ,1989年04期
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