【摘要】 进行离体大鼠心脏灌流,缺氧再给氧后制备心肌匀浆,采用TBA反应比色法测定MDA含量。结果表明;丙酸睾丸素(8μg/kg、64μg/kg)、己烯雌酚(3.2μg/kg、12.8μg/kg)对缺氧、再给氧心肌MDA含量均有明显的降低作用,并分别与抗氧化剂V_E100μM、200μM作用相似,与老化有关。更多还原

【Abstract】 The heart perfusion was carried out in rats in vitro.Following hypoxemia and reoxygenation, herat sarcolemmal was made. Methyldialdehyde (MDA) contents were measured using TBA photocolorimetric method. The results in- dicated that testosterone propionate (8μg/kg, 64μg/kg) and diaethylstilbes- trolum (3.2μg/kg, 12.8μg/kg) could decrease the myocardial MDA contents induced by hypoxemia and reoxygenation and the free radical-induced lipid peroxidation. These results suggest that testosterone propionate and diethylstil- bestrolum may inhibit free radical formation and protect heart muscle from myocardial damage by reperfusion.更多还原