THE ANTAGONISM OF ANGIOTENSIN Ⅱ ON THE DEPRESSOR EFFECT OF CLONIDINE IN RAT SPINAL CORD

【摘要】 <正> There is a large body of evidence to suggest existence of endogenous anti-opioid substances (AOS) in central nervous system to antagonize the actions of endogenous opioid peptides. Angiotensin Ⅱ has been considered as one of the AOS because it was found to antagonize opioid activity in various physiological and pharmacological systems. In present work, we studied the antagonistic effect of angiotensin Ⅱ on the cardiovascular activities of endogenous opioids.更多还原