In the progress of inflammation the phagocytosing granulocytes produce a large amount of the superoxide radical (O2-) that is the starting factor of the active oxygen. Excessive O2 -and other active oxygen aggravate the inflammation. Because superoxide dismutase (SOD) can scavenge O2- , the enzyme has the antiinflammatory activity.Our laboratory has purified the enzyme from fresh bovine blood, and the SOD external preparation that mainly contains SOD has been prepared by filtration. The double blind control...