STUDY ON SOME BIOLOGICALLY ACTIVE CO-ORDINATION COMPOUNDS OF METAL IONS (Ⅰ)——SYNTHESIS,CHARACTERIZATION,STRUCTURE AND ANTITUMOR ACTIVITY OF COMPLEX OF 3,6-DI-(DIMETHYLAMINO)-DIBENZOPY-RIODONIUM LANTHANUM EDTA

【摘要】 <正> The title coordination compound has been synthesized by the reaction of HLaEDTA·7H₂Owith （CH₃）₂N-?-N（CH₃）₂·HCOO^- in ethanol aqueous solution. Thesingle crystal has grown from aqueous solution and has been characterized by IR, TG-DTA,X-ray powder diffraction, molar conductance, UV and ¹H-NMR. The determination of itscrystal and molecular structure shows that it crystallizes in space group P2_1/n with latticeparameters: a = 14.735A, b = 29.335A, c = 16.409A, β = 99.24°, v = 7009.30A³, z = 4,F（000） = 3488, molecular weight M = 1756.90, D_C = 1.665g/cm³. It has been refined by thefull matrix least squares method to final discrepancy factor R = 0.096. The anion [La2（EDTA）₂（H₂O）₄]^2- turns out to be a dimer, in which each of the twoEDTA^4- ions is coordinated to a La³⁺ ion with five of its six coordinating sites and the re-maining sixth one-the oxygen atom of carboxylis bridged to two La³⁺ ions, thus forming aparallelogrammic four-membered ring La₂O₂. The nine coordinations about更多还原

【Abstract】 The title coordination compound has been synthesized by the reaction of HLaEDTA·7H₂Owith （CH₃）₂N-?-N（CH₃）₂·HCOO^- in ethanol aqueous solution. Thesingle crystal has grown from aqueous solution and has been characterized by IR, TG-DTA,X-ray powder diffraction, molar conductance, UV and ¹H-NMR. The determination of itscrystal and molecular structure shows that it crystallizes in space group P2_1/n with latticeparameters: a = 14.735A, b = 29.335A, c = 16.409A, β = 99.24°, v = 7009.30A³, z = 4,F（000） = 3488, molecular weight M = 1756.90, D_C = 1.665g/cm³. It has been refined by thefull matrix least squares method to final discrepancy factor R = 0.096. The anion [La2（EDTA）₂（H₂O）₄]^2- turns out to be a dimer, in which each of the twoEDTA^4- ions is coordinated to a La³⁺ ion with five of its six coordinating sites and the re-maining sixth one-the oxygen atom of carboxylis bridged to two La³⁺ ions, thus forming aparallelogrammic four-membered ring La₂O₂. The nine coordinations about each metal arecompleted by two water molecules. The average bond length is 2.560A for La-O and 2.833Afor La-N. Approximately, the dimer belongs to point group Ci with the centre of inversionat the centre of La₂O₂ parallelogram. The antitumor activity of the coordination compound was studied by observing its effecton the incorporation of ³H-TdR into DNA of leukemia （L7712） cells in vitro. The degree ofinhibition reached 83.9% after exposing 2×10⁵ cells per millilitre to 4×10^-5 mol/L of thecompound for 24 h, being higher than those of its precursors.更多还原