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B-TG影响血管内皮细胞生成PGI2吗?

DOSE β-TG AFFECT PGI2 PRODUCTION BY VASCULAR ENDOTHELIAL CELLS?

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【作者】 陈国强; 任文华; 徐也鲁; 王振义;

【Author】 Chen Guoqiang, Research Institute of Cardiovascular Disease, Hengyang Medical College, Hunan

【机构】 衡阳医学院心血管病研究所; 上海第二医科大学病生教研室; 上海血液学研究所基础研究室;

【摘要】 β—血小板球蛋白(β—TG)是由血小板α——颗粒释放出来的一种特异性蛋白质。迄今,对于它是否抑制血管内皮细胞生成前列环素(PGI2)这一问题尚无定论。本文应用本室纯化的β—TG进行实验,结果未能证实它对牛和猪主动脉内皮细胞生成PGI2有任何影响。同时,在本实验条件下也尚未证实牛主动脉内皮细胞上β—TG特异结合部位的存在。

【Abstract】 β-thromboglobulin (β-TG) is a platelet-specific protein which is released by platelet a-granules. To this day, no final conclusion has yet been reached on whether β-TG inhibits PG I2 production by vascular endothelial cells (VEC). In the thesis, human β-TG which is purified by our own department is used,and any effects of β-TG on PG I2 production by bovine and porcine aortic endothelial cells are not verified. In addition, under our department β-TG specific binding sites on bovine aortic endothelial cells are not found.

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