【摘要】 <正> 我们已对肺癌浸润淋巴细胞的抗肿瘤活性,体外的增殖特征及与自身PBL的比较等进行了研究。实验表明,TIL在体外经rIL-2激活后可出现明显的抗肿瘤活性;在rIL-2存更多还原

【Abstract】 We have reported antitumor activity of lymphocytes infiltrating lung carcinomous tissue and thier in vitro expansion, comparison with autologous PBL. Here we report clinical application of TIL to patients with lung carcinoma who received surgical resection of thier primary lesions for the purpose of destroying free tumor cells in circulation and metastatic micro-loci, and preventing recurrence and metastases. Recombinant IL-2 (2×10~5u/day) were administrated ⅳ for 5 days. On second day, TIL were ⅳ transferred. Temporary low fever appeared in 2 cases among 3. No other toxic effect was observed. The results showed that immunotherapy with autologous TIL plus rIL-2 was safe and applicable.更多还原