【摘要】 本文报道^99mT_C—B_Z—MAG₃药盒的制备方法和动物实验。制备药盒时,以10ml生理盐水溶解200mg葡萄糖酸钙,用0.25N的HCl调节pH5.5,依次加入B_Z—MAG₃ 10mg和SnCl₂·2H₂ O200μg,G₄细菌漏斗过滤,分装成1ml/瓶,置-30℃储存或冷冻干燥后放4℃冰箱保存。本药盒加入^99mT_C O₄ -0.5～3ml,液态和冻干品药盒的标记率均>95％。该药盒具有肾浓聚快、排泄迅速以及无毒性、无热源、无细菌等特点,使用是非常安全的。更多还原

【Abstract】 This paper report a method for the preparation of ^99mT_c--B_z--MAG₃ kits and animal experiments. As preparation kits, 10 millilitre physiological saline dissolved 200 mg gluconic acid Ca and the ph was adjusted to 5.5 with 0.25 N HC1, at last added B_z--MAG₃ 10 mg and SnCl₂·2H₂O 200μg respectively.The liquid were filtered into a berker by G₄ and divided into 1 ml/a vial. The kits were stored frozen or dryed under condition （aqueous and lyoph- ilized, kept at--30℃ and 4℃ respectively）. The both kits were added ^99mT_xO4^-0. 5～3ml, the labeling efficiency was over 95%. The biodistribution of mice showed a rapid uptake and discharge of radioactivity by kidneys. After injection 30 minutes, the remaining radioacti- vity of kidneys only are 0.13% of the injected tolal dose. The time of maximum （Tmax） concentred by kidney is 2±1 minute. The time of half discharge （T 1/2） is 6±1 minute. The kits have no toxic, bacteria, heat source and so on. So the kits are safe.更多还原