【摘要】 作者采用放射免疫法,测定26例正常健康人和40例慢性肺源性心脏病（肺心病）患者（52例次）的血清和尿中的β₂-微球蛋白（β₂-microglobulin,β₂-MG）。结果表明:肺心病患者血清和尿中的β₂-MG（3.86±1.58mg/L和0.66±0.34mg/L）与正常健康人（2.01±0.47mg/L和0.10±0.08mg/L）有极显著性差异（P<0.001和P<0.005）;肺心病并发呼吸衰竭时,血清液和尿的β₂-MG水平与PaCO₂呈正相关,与PaO₂呈负相关。测定β₂-MG可早期发现肺心病的肾功能损伤。作者并对肺心病肾功能损伤的因素进行了讨论。更多还原

【Abstract】 Serum and urine levels of β₂-microglo-bulin（β₂-MG）were measured with radioim-mune assay in 40 chronic cor pulmonale pa-tiens （52 episodes） and 26 normal controls.The results Med that the serum andurine levels of β₂-MG were 2.01±0.47mg/Land 0.10±0.08mg/L respectively. in thenormal controls,while in the cor pulmonalegroup 3.86±1.58mg/L and 0.66±0.34mg/Lrespectively, with statistical significance（P<0.001, <0.005）. It was shown thatthere was a positive correlation betwenthe levels of serum and urine β₂-MG andPaCO₂ and a negative correlation betweenthe levels of serum and urine β₂-MG andPaO₂. The Results indicated that determi-nation of serum and urine β₂-MG could beused in the early detection of the renal im-pairment in chronic cor pulmonale. Thepredisposing factors of renal dysfunction incor pulmonale were also discussed.更多还原