【摘要】 作者对1983年1月至1986年6月住我院诊断为躁狂抑郁症,并符合Dunner快速循环型情感性精神病(RCAD)的27例患者中,仅18例获得为期1年半至4年半的临床随访研究,结果表明,8例有躁郁发作,其中仅1例属快速循环型发作,10例无复发。抑郁发作者对锂盐或停用抗抑郁剂有效,而躁狂发作者对卡马西平反应良好。这些病例治疗反应的差异提示RCAD可能存在生物学的异源性。更多还原

【Abstract】 Of 27 cases, 18 manic-depressive pa-tients who simultaneously fitted dunners’seminal definition about rapid cycling affec-tive disorders (RCAD) completed clinicalfollow-up for 1.5-4.5 years after dischargebetween Jan, 1983 and Jun, 1986. Theresults showed that 8 cases relapsed intomanic-depressive episodes, the other 10 caseshad no relapsed. Only one case belongedto relapsing of RCAD during the follow-upduration. The cases with relapsing ofdepression responded to lithium or to stop-ping use of antidepressants, but the caseswith relapsing of manic episodes respondedto carbamazepine. The differences in thera-peutic response in such cases suggested thatRCAD probably presented biological hetero-genecity.更多还原