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猕猴离体心室乳突肌电生理特性研究

RESEARCH OF THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED VENTRICULAR PAPILLARY MUSCLE OF RHESUS

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【作者】 蓝庭剑; 查忠斌; 王用芬; 林代平; 钟顺玉;

【Author】 Lan Tingjian;Zha Zhongbin;Wang Yongfen Lin Daiping;Zhong Shunyu Department of Physiology,School of Basic Medical Sciences

【机构】 华西医大基础医学院生理学教研室; 成都军区卫生学校 进修教师;

【摘要】 作者采用细胞内微电极技术,对8只四川猕猴30个离体心室乳突肌的静息电位、动作电位、超射值、动作电位时程(APD)中的APD20、APD50、APD90、APD100,以及0期最大去极速度与有效不应期等电生理活动进行了测量和研究,并比较了猕猴与其他哺乳动物的各项电生理参数。结果表明它们极其相似,故推测它们具有相近的电生理学特性。

【Abstract】 The electrophysiological properties ofcardiac muscle of rhesus (Macaca mulatta)by use of intracellular electrode techniquehas been described in this paper. Thirtypapillary muscle from 8 rhesus were used forthis research and 68 succesful records hadbeen obtained. The valae of resting poten-tial is -86.26±7.57mV (M±SD). The confi-guration of the action potential is typical forthe ventricular muscle of mammalian. Theamplitude of action potential is 118.80±10.69mV; over-shoot is 25.57±6.11mV. TheAPD20, APD50,APD?0, APD100 is 184.33±64.04, 301.02±95.32, 382.17±125.81 and436.33±122.39 ms, respectively. The maxi-mum depolarization velocity of 0 phase is101.20±17.59 V/s. The effective refractoryperiod is 292.69±93.91ms. Comparing theresults of the rhesus cardiac muscle withthat of other mammalians, authors foundthat they were very similar. It is suggestedthat the results and analysis of its mecha-nism derived from investigation of othermammalian cardiac tissues are applicable tothe human.

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