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自然环境中分离出致病性自由生活阿米巴

ISOLATION OF PATHOGENIC FREE-LIVING AMOEBAE FROM NATURAL ENVIRONMENT

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【作者】 彭晓谋刘多谢长松聂崇兴

【Author】 Peng Xiaomou Liu Duo Xie Changsong Nie ZongxingDepartment of Parasitology, Hunan Medical University

【机构】 湖南医科大学寄生虫学教研室湖南医科大学寄生虫学教研室湖南医科大学寄生虫学教研室湖南医科大学寄生虫学教研室 湖南省儿童医院传染科 研究生

【摘要】 湘江、泳池等水源中采集样本236个,其中77.5%有自由生活阿米巴(FLA)生长,从属于9种不同类型。65个阳性样本经鼻滴注小鼠作致病试验,筛选出4个致病性FLA分离物。该分离物使部分小鼠死于阿米巴脑炎。死亡小鼠脑、鼻粘膜等组织可见棘阿米巴滋养体和包囊。进一步观察证明。此阿米巴经鼻粘膜和筛孔直接侵犯中枢神经系统,该种阿米巴初步鉴定为多噬棘阿米巴。

【Abstract】 A cultivated method for isolation of free-living amoebae ( FLA) was conducted with samples from Xiangjiang River, warm spring water, pond, sewage of power plant and swimming pool. Out of 236 water and soil samples, 183 (77.5%) contained nine different species of FLA. Out of 183 positive samples, 65 were tested their pathogenicity in mice. A.polyphaga isolated could put 12.5-25% LACA mice and 50% outbred mice to death within 5 to 21 days when inoculated intranasally. These amoebae entered the central nervous system by the nasal mncosa to olfactory bulbs route.There were inflammatory lesions in nasal mucosa, leptomeninges and brain parenchyma.

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