【摘要】 本文叙述制备放射性氯化亚铊(²⁰¹Tl)注射液的方法。靶子为高纯金属铊片,装于具有水冷、气冷腔的2π靶室内,利用扇形聚焦回旋加速器所产生的30MeV质子进行辐照。靶片溶解后,联合使用液-液萃取和阴离子交换法进行化学处理,可同时获得无载体²⁰³Pb。产品²⁰¹Tl核纯度大于99％(²⁰⁰Tl～0.76％,²⁰²Tl～0.04％),放化纯度大于98％,含铊量小于0.27×10^-7μg/Bq（1.0μg/mCi）²⁰¹Tl。化学杂质Fe、Al等均小于1ppm,²⁰¹Tl厚靶产额约为18.8MBq/μAh。产品经临床前药理试验、药检试验和临床试用,质量良好。更多还原

【Abstract】 The production of thallous chloride 201T1 injection is described. 201T1 was produced via nuclear reaction of 203Tl(p, 3n) 201Pb.using natural thallium in a specially designed 2π cooling target system. The separation of Pb-activity from the Tl target was carriedout by extraction of Tl(Ⅲ) with isopropyl ether and purification of Pb(Ⅱ) with an anion exchanger (201 × 8 resin) column. After a decay time of 32h, during which an optimum growth of 201T1 took place, carrier-free 201T1 was separated from the 203Pb activities by a second similar anion exchanger.Dependences of the percentage extraction of Tl(Ⅲ) from HCl solution into isopropyl ether on acidity and concentration of Tl (Ⅲ) in aqueous phase were determined. The thick target yield of 201T1 is 18.8MBq/μAh. The product possesses a radioisotopic purity of >99% and a radiochemical purity of >98%lt is a sterile, isotonic and pyrogen-free solution with a Tl content of 0.27×10-7μg/Bq-更多还原