【摘要】 通过复制家兔动脉粥样硬化(As)模型,初步探讨实验前、后家兔 LPL 活性及其与病理变化的关系。同时检测了血脂水平。实验组 PH—LPL 活性于实验后4周开始降低,尤以13周为明显(P<0.01);13周时成活的11只兔中,有8只主动脉呈现不同程度的病变(霞度4只,中度1只,轻度3只),且与 PH—LPL 活性呈负相关(r_s=-0.685,P<0.05)。PH—LPL 活性差值(与实验前);重度>0.965mmol/L/h,中、轻度0.820～0.540mmol/L/h,<0.300mmol/L/h 为As 病变较难形成,因此,PH—LPL 活性在估计主动脉病变的有无和程度上有一定意义。更多还原

【Abstract】 The ralationship between LPL activity and pathologic changes before and after the experiment was preliminarily investigated through experimental atherosclerotic rabbits.The blood lipid level was also measured through- out the study. In the experimental group the activity of PH-LPL began to decline in the fourth week after the begining of the experiment and changed signifi- cantly(P<0,05)in the thirteenth week.In the thirteenth week,8 of the 11 survived rabbits showed pathologic changes of varied degrees in the aorta. A significant negtive correlation(r=-0.685,P<0.05)was demonstrated be- tween the severity of pathologic changes and PH-LPL activities.Compared with the measurements done before the experiment,the study showed a dif- ference of PH-LPL activity greater than 0.965mmoIL/h in the cases with severe pathologic change and 0.620～0.54Omml/L/h in those with moderate and mild pathologic changes.Those with PH-LPL activity difference less than 0.300mmot/L/h did not show the formation of atherosclerosis in the aorta.The results suggest that PH-LPL activity might have the value to es- timate the existance of atherosclerosis and its severity.更多还原