【摘要】 翠雀固灵(DS)对氯仿引起的小鼠室颤、肾上腺素引起的兔心律失常有明显的对抗作用,且能明显提高兔心室电致颤阈。此外,DS能降低蟾蜍坐骨神经干动作电位的振幅,提示它对钠通道有阻断作用。然而,DS的神经节阻滞和直接抑制心脏可能是其抗心律失常作用的主要机制。更多还原

【Abstract】 Delsoline ( DS ) is not only effective in preventing ventricular fibrillation ( induced by chloroform in mice ) and arrythmia ( induced by adrenalin in rabbits), but can raise the intebsity of the threthold of electrical shocks to cause ventricular fibrillation in rabbits.Furthermore , DS can obviously inhibit the action potential amplitude of isolated sciatic nerves in toads, indicating that it can block sodium channels. However, the antiarrythmic effect of DS may be mainly attributed to itsganglionic blocking and negative cardiac inotropic effect.更多还原