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急性胰腺炎早期(术后3天)时胰胆胃肠功能的变化及栀子的影响

EFFECT OF CAPEJASMINE ON PANCREATIC, BILIARY, GASTRIC AND INTESTINAL FUNCTION AT THE EARLY STAGE (3RD DAY) OF EXPERIMENTAL ACUTE PANCREATITIS

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【作者】 高静涛; 裴德恺; 姜妙娜; 姜淑珍;

【Author】 Gao Jingtao, Department of Pathophysiology, Dalian Medical College.

【机构】 大连医学院病生教研室; 大连医学院病生教研室;

【摘要】 本工作就急性胰炎诱发3天后消化器官功能的变化及栀子的治疗影响进行探讨。实验分3组进行、胰炎喂栀子组,胰炎喂盐水组及正常组。以向胰管内注入1.5%去氧胆酸钠诱发胰炎,在术前及术后每天喂一次栀子或生理盐水,观察胰液分泌量及淀粉酶含量、胆汁分泌量及胆汁酸、HCO3-含量、胃酸分泌量、小肠对葡萄糖的吸收等的变化。结果显示:胰炎3天后胰液、胆汁分泌量及小肠吸收葡萄糖量已恢复正常,但淀粉酶和胆汁酸含量仍然很低,胃酸分泌明显抑制。栀子治疗似乎有利于这些功能的恢复。

【Abstract】 SD rats were induced acute pancreatitis with 1.5% DCA-Na through intra-pancreatic duct retrograde injection and divided into 2 groups according 50% Capejasmine decoction or saline peroral infusion 1 hour and after operation one time per day for 3 days. The pancreatic, biliary, gastric and intestinal functions were observed at the 3 rd day after operation and compared with normal animals. It was demonstrated that the secretory of pancreatic juice and bile and the glucose absorptive function of jejunum were almost nearly normal, but the content of pancreatic amylase, bile acid and gastric acid were still lower than normal. It seemed that these functions restored better in the group which treated with herb.

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