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三磷腺苷氯化镁治疗氨基半乳糖所致大鼠肝坏死的初步研究
PRELIMINARY RESEARCH INTO TREATMENT OF THE EXPERIMENTAL HEPATIC NECROSIS INDUCED BY D-GALACTO SAMINE WITH ADENOSINE TRIPHOSPHATE-MAGNESIUM CHLORIDE
【摘要】 采用D-Gal将大鼠做成实验性肝坏死,分别以ATP及ATP-MgCl2治疗结果表明,ATP-MgCl2组无一死亡,[3H]TdR肝内掺入量与模型组比较有极显著差异(P<9.01),肝坏死程度较轻,在残存的肝细胞浆中肝糖原颗粒和线粒体数量较对照组及ATP组更为丰富,且超过正常组。提示对急性肝坏死尽早使用ATP-MgCl2,可减轻肝脏坏死程度,并促进肝细胞蛋白质及DNA的合成,从而加速肝细胞的再生和修复。
【Abstract】 The experimental hepatic necrosis induced by D-galactosamine was treated by ATP and ATP-MgCl2, respectively.The results showed that the degree of hepatic necrosis in the ATP-MgCl2 group was milder than that in the control group and ATP group.It is suggested that ATP-MgCl2 could reduce the hepatic jnjury and accelerate the regeneration of the hepatic cells in the experimental hepatic injury.
【关键词】 D-氨基半乳糖;
肝坏死;
三磷腺苷氯化镁;
疾病模型;
动物;
【Key words】 D-galactosamine; hepatic necrosis; ATP-MgCl2; disease models,animal;
【Key words】 D-galactosamine; hepatic necrosis; ATP-MgCl2; disease models,animal;
- 【文献出处】 第二军医大学学报 ,Academic Journal of Second Military Medical University , 编辑部邮箱 ,1989年02期
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