【摘要】 对22例新月体性肾小球肾炎用光镜、电镜、免疫病理学方法进了病理学研究。免疫复合物沉积(12例)、抗基膜抗体(3例)及不明原因(6例),均可严重损伤肾小球,血液有形成分积纤维蛋白涌入肾小囊,导致新月体形成。新月体细胞具有肾小囊上皮细胞的超微形态,细胞间有基膜样物质形成,单核巨噬细胞弥漫、均匀地分布于肾组织,从而证明新月体主要由上皮细胞增生而形成。更多还原

【Abstract】 19 renal biopses and 3 autopses with crescentic glomerulonephritis were observed by LM. EM, direct IF. and immunohistochemistry method (ABC method). The antibody of lysozyme and alpha-1-antichymotrypsin were used to disply macrophagocytes.The cells of crescents had ultrastructure characteristic of glomerular parietal cells. Basement membrane material was formed between the cells of crescents. Mononuclear phagocytes showed well-distributed in glomerular tufts, crescents and interstitial tissue. The ressults indicated that origin of crescentic cells were mostly from proliferating glomerular parietal epithelial cells and with some glomerular visceral epithelial cells, although some infiltrating mononuclear phagocytes were present.The severe damage of glomerular capillary walls, fibrinogen and blood cells got into Bowman’s capsule space and then crescents formed. 22 crescentic glomerulonephritis included 13 cases of immune complex glomerulonephritis, 3 cases of anti-GBM glomerulonephritis and no evidence of immune mechanisms for 6 cases. So immune complex deposits were the common cause of damage of glomerular capillary walls.更多还原