【摘要】 <正> 过去我们曾经报告,人工合成的心钠素(PL 058)较心钠素具有更为强大的降压作用(谢翠微等,中华医学杂志1986;66∶650.)。其生物半衰期亦较心钠素长(北医大学报1988;20∶227.)。强啡肽可以刺激心钠素的释放,亦具有降压作用(Tang.et al.Europ J pharmacol 1987;136∶449.)。本工作研究心钠素衍生物(PL 058)和强啡肽对自发性高血压大鼠(SHR)血压的影响。更多还原

【Abstract】 The dynorphin A can release atriopeptin from rat atrium. The involvement of dynorphin, atriope-ptin, and its analog (PL 058) in hypertension was investigated in SHR. It was found that intravenpus injection of dynorphin (81-324nmol/kg), atriopeptin Ⅲ and PL 058 (10nmol/kg) markedly decreased the mean arterial pressure in anaesthetized SHR. The depressor effect of PL 058 was stronger than that of atriopeptin on both normotensive rats and SHR. It was also found that deprrssor effect of atriopeptin Ⅲ and PL 058 in normotensive rats was significantly greater than in SHR. It is concluded that the effect of atriopeptin on SHR was less than on normotensive rats.更多还原