【摘要】 <正> 文献报道雌激素可以促进胆囊结石的生成,但机理还不十分清楚。本研究拟通过动物试验探讨雌激素在胆囊结石形成过程中的作用,并观察某些中药对结石形成的预防效应及其作用环节。材料与方法雌性金黄地鼠(Golden SyrianHamster)60只,平均体重50g,喂正常饲料1周后,更多还原

【Abstract】 A new hamster model of cholesterol cholelithiasis induced by estrogen and closely simulating the human situation was used.Sixty female golden Syrian hamsters(average weight 50±1g)were allocated to 5 groups of 12 animals each.One group was fed with normal diet(containing 0.8 mg chol. /g of food)as control.Two groups were fed with high cholesterol diet(containing 2.4 mg chol./g of food)with or without ethinyl estradiol(EE),15μg/kg per day.Another two groups receiving both high cholesterol and EE,also received either composite Artemisia decoction or Artemisia decoction. The animals were sacrificed at the 12th week.Cholesterol gallstones formed in 58% of those fed with the combination of both increased cholesterol and EE.The cholesterol concentration of bile was higher in this group.In the groups receiving Chinese herbal medicine,cholesterol gallstone formed in 16% and 41% respectively,with low cholesterol concentration in bile.In animal receiving composite Artemisia decoction the hepatic HMG-CoA reactivity were reduced(P<0.05)when compared to the group fed with the combination of cholesterol and EE.Thus,we presented a new way to prevent gallstone formation.Further investigation in the clinical trial of these medicine is to be taken.更多还原