【摘要】 <正> 我国胃癌病因综合考察发现胃癌高发区食品及胃液内真菌污染严重,其中产毒真菌以染色曲霉占首位,检出率明显高于胃癌低发区,并与慢性胃炎病变有相关关系,其次为构巢曲霉和黄曲霉。这些真菌代谢产生的毒素都具有致突变和致癌作用。 真菌毒素的检测在国内多用薄层色谱法在食物样品中进行,尚未见人胃液内真菌毒素研究的报道。本研究用高效液相色谱(HPLC)法对胃癌高发区居民常吃的酸菜及与胃癌有密切关系的慢性胃炎患者更多还原

【Abstract】 By HPLC, trace levels of aflatoxin B2 and G2 were determined in two kinds of pickledvegetables collected from Wuwei county, a high-risk area of gastric cancer. No significantdifferences in the positive rates and mean values were seen. The mutagenic and carcinogenicsterigmatocystin and low toxic versicolorin A were found in the pickled vegetables withclear soup. The positive rates were 23.1 and 38.5%, and the mean values were 18.2 and37.2 ppb respectively. But these two kinds of mycotoxins of Aspergillus versicolor were allnegative in pickled vegetables with sour paste. Sterigmatocystin was also found in the fasting gastric juice in patients with chronicgastritis from Putian county, another high-risk area of gastric cancer, with postive rateand mean value of 25.0% and 23.7ppb respectively. Interestingly, only versicolorin A wasdetected in the same kind of gastric juice samples collected from Huaxi, a low-risk area ofgastric cancer. The positive rate and mean value were 23.0% and 61.8ppb respectively. Nosterigmatocystin was found. No prevous reports were seen on the mycotoxin investigation in gastric juice. Therelationship between gastric cancer and sterigmatocystin is not clear.更多还原