【摘要】 <正> 乳腺癌的流行病学和动物实验研究表明,卵巢激素[雌酮（E₁）,雌二醇（E₂）,孕酮（P₀）]和垂体激素[催乳素（PRL）]能影响乳腺癌和良性乳腺疾病的发生和发展。但对乳腺疾病血清激素的改变尚无更多还原

【Abstract】 In this study sera specimens from 47 premenopausal women with breast cancer (Ca)and normal controls were collected for analysis. Cases and controls were matched for age(±2 yr), height (±7 cm). body weight (±2 kg), menstrual status and pregnancy status.The specimens were collected at 11th day (the follicular phase) and 22th day (the lutealphase) of a single menstrual cycle. The estrone (E1), estradiol (E2), nonprotein-bound E2(NPB E2), sex hormone binding globulin (SHBG), prolactin (PRL) and progesterone(Po) levels were compared between two groups. We found no significant differences in EI,E2, NPB E2 and SHBG only prolaction (22th day) and progesterone (Ⅱth day) levels wereelevated in women with Ca. After adjusting for cycle length less than 35 days in 39 pairs.women with Ca were found to have significantly higher geometric mean progesterone levelthan controls (2-sided, P=0.05) and slightly higher geometric mean prolactin level thancontrols (2-sided, P=0.08). Our findings suggest that elevated serum Po and PRL levelsmay be associated with increased risk of breast cancer.更多还原