【摘要】 <正> 血清类粘蛋白（Orosomucoid,α₁-Acidglycoprotein.以下简称AGP）是一种酸溶性、低分子量（40,000）的急相期蛋白。在多种癌症患者血清中的含量均升高,可作为肿瘤辅助诊断和疗效监视指标。但目前临更多还原

【Abstract】 This paper describes the discrimination of the microheterogeneity of AGP （α₁-AcidGlycoprotein）in lung cancer, tuberculosis and normal individual. The concentration of AGPwas measured in sera from 31 patients with lung cancer, 30 patients with tuberculosis-and 30 normal individuals. All sera were further subjected to crossed immuo-affinoelectro-phoresis with addition of ConA in the first dimension and antibodies against humanAGP in the second dimension. AGP in the lung cancer group was divided into threemicroheterogeneous fractions i. e. the non ConA binding fraction（peak Ⅰ）,the weak-ConAbinding fraction （peak Ⅱ） and strong-ConA binding fraction （peak Ⅲ）; AGP in thenormal group and in the 26/30 tuberculosis were divided into two fractions i. e. the non-ConA binding fraction （peak Ⅰ） and the weak-ConA binding fraction （peak Ⅱ）. The individualfractions were given as the percentage of total amount of AGP. The percentage ofnon-ConA binding of normal health.tuberculosis and lung cancer was 54.10±4.80,45.28±8.76 and 48.64±4.65 respectively. The percentage of weak-ConA binding fraction ofthese three groups was 46.80±3.68, 50.01±19.61 and 40.63±2.89 respectively. Thepercentage of strong-ConA binding fraction were 4.62±6.31 and 11.01±3.04. Thus themicroheterogeneous patterns of AGP in the three groups were significantly differentfrom each other.更多还原