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七宝美髯丹的抗凝血作用研究
Effect of Qi Bao Mei Ran Dan on coagulation
【摘要】 七宝美髯丹乙醇提取物具有抗凝血作用,能明显延长家免的出血时间和凝血时间。降低血小板数和血小板粘附功能,延长血小板第Ⅰ、Ⅳ因子时间。
【Abstract】 Qi Bao Mei Ran Dan was administered orally at dose of 6g/kg for study of its blood coagulation, platelet function and hematocrit, Blood sedimentation, the results were as follow;( 1 ) The platelet couns was reduced, the platelet factorl, 4. were significantly prolong time. The drug prevent the function of platelet adhere.( 2 ) The prolonged bleeding time coagulation time and prothrombin time indicated that the blood coagulation was inhibited.(3) The plasma protamine paracoagulation test (3p test) shows positive respose.(4) Hematocrit and Blood sedimentationrate were significantly changs. All these results suggest that Qi Bao Mei Ran Dan posesses an inhibitory function on blood coagulation.These changes may be responsible for its platelet function.
- 【文献出处】 中药药理与临床 ,Pharmacology and Clinics of Chinese Materia Medica , 编辑部邮箱 ,1988年04期
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