【摘要】 用17-FE细胞化学法测定41例女性乳腺癌患者雌激素受体(ER),并观察其与肿瘤细胞对5-FU敏感性的关系。30例作短期化疗后,平均ER阳性细胞率从12.4％升至18.6％(P<0.02),化疗前ER阴性者上升更明显,提示ER阴性者肿瘤细胞分化差,对5-FU更敏感;11例作原代细胞培养及药物敏感试验,高敏组ER阳性细胞率低而核仁ER阳性率高,提示ER状态在一定程度上可预测肿瘤细胞对化疗药物的敏感性。更多还原

【Abstract】 Estrogen receptor (ER) status and change of patterns were studied in 41 female patients with breast cancer using 17-FE cytochemical method. Among them, 30 patients received a short course of 5-FU (500mg/d×3) before operation. ER and (3H) thymidine labelling index (LI) were determined before and after chemotherapy. A significant increase of ER positi-vity rate (from 12.4% to 18.6% ,P<0.02) after chemotherapy were observed. In the remaining 11 cases, surgical specimens were taken for 5-FU sensitivity test on primary cell culture for evaluation of chemosensitivity using Giemsa stain and LI inhibition test. The correlation between LI and ER, LI and clinical stages was analysed. The potential value of ER as an indicator for drug sensitivity was discussed.更多还原