【摘要】 <正> 本院自1984年6月至1987年3月,用国产CEA药盒(上海化学试剂研究所),放免测定法,共对162例经手术及病理证实的大肠癌患者作了术前血清癌胚抗原(CEA)浓度的测定,本文分析比较血清CEA与肿瘤病理分期、肿瘤浸润程度、手术方式、预后等的关系,以评价术前CEA在大肠癌应用的临床价值。 一般资料 正常对照组为84例健康献血员,平均CEA值为10.81±2.55ng/ml,故本院外科实验室的血清CEA正常值为15ng/ml以下,≥15ng/ml者为阳性,>25ng/ml者为明显升高。 肿瘤病理分期采用1984年苏州会议提出的大肠癌Dukes—中国改良法诊断标准,分A、B、C、D四更多还原

【Abstract】 This report analyses preoperative serum carcinoembryonic antigen (CEA) determination in 362 patients with colorectal carcinoma in recent three years. We found that there was a strong relationship between preoperative serum CEA level and Dukes class. The CEA positivity rate and the mean value increased with each Dukes category significantly (P<0.01, P<0.01)-A correlation was evident between preoperative CEA level and tumor extension. Preoperative CEA correlated with surgical managements, also with degree of lumen encirclement by tumor. In D stage, one year survival rate was significant different (P<0.01) between the preoperative CEA level lower and higher than 25 ng/ml. The results show that, though the preoperative serum CEA determination might not be as a major method in diagnosing early disease, it can be used as an adjunct to clinical pathological staging methods. It helps to evaluate the tumor involvement before surgery. A low concentration indicates an early stage of the tumor, while a high concentration indicates a wide spread of the disease, or distant metastases, and a lower possibility of radical resection. It can be a valuable parameter of prognosis, as well as a reference of postoperative therapeutic strategy. Thus, the preoperative serum CEA assay is a valuable biochemistric test in patients with colorectal carcinoma.更多还原