【摘要】 <正> 测定半数致死量LD₅₀（或半数有效量ED50）是药理学、毒理学的一项经常性重要工作。其计算方法一般认为以Bliss氏早年提出的算法最严谨、精确。但由于人工计算繁杂、费时,该法末能得到推广。本文作者用BASIC语言编制了带作图的该法计算LD50的计算程序。 计算基本步骤及框图 按本法计算LD₅₀的过程,其基本步骤是:①从原始数据求死亡概率单位对剂量对数的回归方程（第零次逼近）;②从第j次逼近的（加权）回归方程计算第（j+1）次逼近的加权回归方程;③若第（j+1）次加权回归方程不能满足精度要求,则再次进行步骤②;④求LD₅₀及其95％可信限、LD1、LD5、LD99和回归系数标准误SB等参数;⑤作图。更多还原

【Abstract】 The author compiled a BASIC program computing LD50 with figure by Bliss method. Using this program is high-speed and convenient. The computed result is accurate. Design of dosage is not necessarily according geometric series. The number of animals of each group is not necessarily equal. The maximal mortality is not necessarily 100% and the minimal mortality is not necessarily zero. If control mortality is not zero, each experiment mortality will be corrected. Printed diagram is distinct.更多还原