【摘要】 <正> 癌胚抗原(CEA)测定作为消化道癌肿的一种诊断方法,由于其敏感性及特异性不强,其意义为大多数作者所否定,但在判断预后,估计手术后存活期和监视手术后癌肿复发等方面的作用,已经受到普遍的重视。有关手术前血清CEA水平与癌肿预后的关系,国外报道以大肠癌较多,胃癌较少。本文旨在探讨术前CAE测定与胃癌预后的关系。 材料和方法 一、病例资料 研究对象为1984年7月至1987年3月我院胃肠外科组收治的病理组织学为腺癌的胃癌96例,由于其他原因而手术前未测定血清CEA的病例未包括在内。96例中,男71例,女25例,平均年龄55岁。96例中,肿瘤位于胃窦部45例(46.9％),胃底贲门部33例(34.4％),胃体部15例(15.6％)。更多还原

【Abstract】 In order to demonstrate a prognosic value of CEA levels, we determined preoperative CEA in sera of 96 patients with gastric cancer and compared these data with the duration of the symptoms, tumor size and extension, the histological types of the carcinomas, the histopatholo-gic, clinical staging and resectability. The results show serum levels were clearly influenced by the histological classifications, clinical staging of the tumour and tumor extention, but not by the duration of the symptoms, tumour size and grade. CEA positive rate were higher in patients with hepatic metastasis than in those without hepatic metastasis (P<0.05)- Stage Ⅲ and Ⅳ patents had a significantly higher CEA levels than stage Ⅰ and Ⅱ patients. Distinct preoperative CEA ranges exhibited significant differences in survival. We conclude the preopc rative CEA has a prognostic value. A low concentration indicates an early stage of the gastric cancer, while a high concentration indicates a wide spread of the disease.更多还原