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甜菊总甙苦味组分对小鼠免疫功能的影响

The Preliminary Studies on Immunocompetence in Mice of Bitters Component (SVK) of Stevioside Extracted from Stevia rebaudiana Bertoni

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【作者】 区淑仪; 黄永楷; 郑永权; 马驱; 李经略; 肖丽文;

【Author】 Ou Shuyi Huang Yongkai Zheng Yongquan (Department of Pharmacology)Li Jinglue Xiao Liwen (Laboratory of Immunology, First Affiliated Hospital)

【机构】 中山医科大学药理教研室; 广东制药厂; 中山医科大学第一附属医院免疫室; 中山医科大学第一附属医院免疫室 药理进修生;

【摘要】 <正> 甜叶菊(Stevia rebaudiana Bertoni),原产于南美,当地作为甜茶饮用。以甜菊的叶子作原料提炼的甜菊精,已作为高甜度、低热量的天然健康糖料应用于食品工业。在提炼甜菊精的过程中,有一种带苦味的副产品,为了充分利用甜叶菊资源,我们研究了此苦味副产品对动物免疫功能的影响,发现它有一定的免疫抑制作用。现报道如下。

【Abstract】 Stevioside (SV) which is extracted fron Stevia rebaudiana Bertoni has been used as a replacement of sugar since 1970s, it is a low caloric and high sweet substance. This paper studies the immunological effect of SVK on mices1. SVK had a suppressive effect on NIH mice on carbon clearance of blood and antibody production in maximal tolerance dose.2. SVK had a synergic effect with prednisolone on decreasing thymus weight but had not significant effect on lymphocyte transfer rate in mice.The experimental results suggested that SVK might be used as an immunosuppressant, its effect and clinical use needs further research.

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