【摘要】 <正> 扰人纤维蛋白原单克隆抗体是研究血栓形成、纤维蛋白溶解、以及纤维蛋白原结构和功能关系的有用工具。近年来,国外已制备了有关的单克隆抗体,并开展了研究工作。我们于1985年开展了抗体纤维蛋白原单克隆抗体的研制工作,现已成功地得到了一组抗人纤维蛋白原单克隆抗体(命名为HIF)。本文仅就HIF的特异性及其对血液凝固功能的影响作一初步报告。更多还原

【Abstract】 This paper reports the biological characteristics of a group of anti-humanfibrinogen monoclonal antibody(McAb),termed HIF series,prepared in ourlaboratory.Results showed that some HIF McAbs reacted to human fibrino-gen and its fragments specifically no cross-reaction with human serum(1:5),bovin fibrinogen,rabbit plasma and serum was found expcept for HIF-4which expressed cross-reaction with rabbit plasma. A part of HIF McAbs(HIF-2,4,10)appeared precipitation band on immunodiffusion and immunoelectrophoresis test.It is possible that some HIF McAbsmight recognize multiple antigen determinats.Therefor,HIF series includeddiverse specificity of anti-fibrinogen. Some of HIF McAbs inhibited coagulation of blood,clot retraction and pla-telet aggregation.It is possible that the polymerization of fibrin monomer andthe bridge-binding action of plateles were inhibited by HIF McAbs,So thatHIF McAbs may be used to prevent high coagulation and thrombosis.更多还原