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癌灵1号注射液对人肝癌细胞杀伤动力学研究

CLINICAL AND EXPERIMENTAL STUDIES OF TREATING ACUTE NON-LYMPHATIC LEUKEMIA WITH AILING-L INJECTION.PART THREE:PHAR-MACODYNAMIC STUDY OF KILLING EFFECT OF AILING-L ON CANCER CELLS

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【作者】 李元善; 张亭栋; 王兴楁; 刘旭;

【Author】 Li Yuanshan Fitst Hospital of Harbin Medical ColIege

【机构】 哈尔滨医科大学附属第一医院; 哈尔滨医科大学附属第一医院; 哈尔滨医科大学附属肿瘤研究所;

【摘要】 <正> 癌灵1号注射液系哈医大附属第一医院自制的抗癌药物,内含中药砒石、轻粉,1972年以来应用临床治疗急性非淋巴细胞白血病,效果满意1。1981年配合手术切除治疗42例晚期原发性肝癌,3年生存率42%,其中5例生存5年以上,而单纯手术组3

【Abstract】 In recent ten years and over , notable therapeutic effects have been obtainedin treating acnte non-ly mphatic leukemia with Ailing-1, and in treating advancedprimary liver cancer with operation combining Ailing-1,By use of autoradiogra-phy, experimental observations on the pharmacody namic effects of Ailing-1 on livercancer cells (QGY-7703) have been catried out. The results show that Ailing-1 in-jection markedly inhibits the growth and survival of the cancer ddlls, but has noinhibitory effect on the division of the cancer cells.Ailing-1 produced differentdegrees of inhibitory effect at different concentratios. showing dose-effect rela-tionship . Ailing-1 directly wouuds or kills cells by deactivating cellnlar enzyme sys-tem.and checking cellular oxidation and respiratian. It is concluded that Ailing-I is s new promising antineoplastic agent.

  • 【文献出处】 肿瘤防治研究 ,Cancer Research on Prevention and Treatment , 编辑部邮箱 ,1988年01期
  • 【被引频次】8
  • 【下载频次】106
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