【摘要】 本文应用雄性小鼠生殖细胞程序外DNA合成(UDS)检测方法研究了呋喃妥因和呋喃西林对雄性生殖细胞DNA的损伤作用。发现两种药物诱发的UDS与药物剂量呈线性正相关,但对精子数量无明显影响。提示两种药物的遗传毒理作用应引起注意。更多还原

【Abstract】 Nitrofurantoin and nitrofurazone were injected intraperitoneally into mice. ~3H-TdR was injected into both testicles. On the seventeenth day after treatment, sperms from the caudal epididymides were counted and incorporation of ~3H-TdR into sperm DNA was determined by scintillometer. Adinistration of 10, 20mg/kg nitrofurantoin and 20 mg/kg nitrofurazone caused higher incorporation of ~3H-TdR than control; this increase was statistically significant. If the injection of ~3H-TdR was taken after 4 hours of the treatment with nitrofurans, the incorporation decreased. No significant difference in number of sperms was noted between the treatment and the control. This study evidenced that nitrofurantoin and nitrofurazone, or their metabolites, reac hed the germ cells of adult mice in suffi cient amounts to produce DNA damage. But, time of their action, was short and they produced less damage than MMS. They did not affect the development of the germ cells of male mice.更多还原