【摘要】 改进了雌三醇(4)的合成工艺,系由3,17-二乙酰氧基雌甾-1,3,5(10),16-四烯(2)经硼氢化反应直接合成。对硼氢化反应的条件进行了考察,4的收率可达到85～90%。闪式柱层析还分离出二个副产物:表雌三醇(5)和17-乙氧基雌三醇(6)。更多还原

【Abstract】 Estriol(4)was synthesized in 85～90% yield from estra-1,3,5(10),16-tetraen-3,17-diol 3,17-diacetate(2)by hydroboration procedure.It wasfound that some reaction conditions(e.g.,temperature,molar ratio)were critical.Two by-products,epi-estriol(5)and estriol 17-ethyl ether(6)were also seperatedby flash chromatography.更多还原