【摘要】 为避免前文工艺中缩酮化和重排反应耗时长的缺点,将反应步骤改为丙酰萘甲醚先缩酮化后再溴化;所得溴代缩酮4再用氯化锌在甲苯中重排,从而使反应周期缩短30h 以上,总收率高,并割除了原甲酸三乙酯。更多还原

【Abstract】 The ketalization of 2-propionyl-6-methoxynaphthalene(2)affordedthe ethylene ketal(3),which was brominated to give the bromoketal(4).Therearrangement of 4 followed by saponification and acidification provided naproxenin high overall yield.This process has the advantage of shorter reaction periodand does not require the expensive ethyl orthoformate.更多还原