【摘要】 本文报告正常成人及垂体GH瘤患者各种治疗前后血清hGH水平对TRH的反应。作者建议以hGH净增值>6.0ng/ml,且较对照值升高50％以上为阳性反应标准。溴隐亭短期治疗后,无论血hGH基础水平下降与否,其对TRH刺激反应多保持不变,提示此反应是由瘤细胞本质决定的。手术及/或放疗后,TRH反应转阴者病情缓解或治愈;TRH反应可疑及阳性者病情仍活动,提示此试验可作为“肿瘤标志”。作者对生长激素TRH试验阳性的可能机制进行了讨论。更多还原

【Abstract】 The response of serum hGH to TRH stimulation was studied in 33 normal adults and 35 patients with pituitary GH-secreting adenoma before and after treatment. The results showed that a net increment of serum hGH level of mor than 6.0 ng / ml together with an increment of serum hGH over basal level by more than 50% should be taken as a positive response.After treatment with bromocriptine over 5 weeks, most of the response of serum hGH to TRH remained unchanged regardless of whether the basal hGH level bad decreased or not. The disease was remittent or cured in those whose TRH response became negative after pituitary surgery and / or pituitary radiotherapy. A persistent positive or possibly positive response after treatment suggested that the disease remained active. Tne results indicated that this test could be used as a tumor marker.The possible mechanisms responsible for the positive TRH test in acromegaly were discussed.更多还原