【摘要】 本文报告了杀菌剂三环唑（又名克瘟唑）毒理学研究的初步结果,三环唑原药（80.61%）对大鼠经口LD₅₀雌雄分别为619、369mg/kg,小鼠雌雄性均为1260mg/kg,大鼠经皮>2000mg/kg,蓄积系数K>5.0,,冲击量试验表明大鼠对三环唑无明显耐受现象。九十天喂养试验表明除500ppm以上可使动物肝/体比增加,对体重、进食量及食物利用率有明显影响外,未见明显中毒症状,血象、心电图、肝、肾功能等均未见异常。初步提出了最大无作用剂量雌性为200ppm或11.2—13.3mg/kg,雄性为500ppm或27.0—30.5mg/kg的建议。致畸试验结果除对胎鼠的生长发育有一定影响外,未见明显畸形及内脏异常。纯品的快筛致突变试验包括Ames试验,DNA损伤修复试验及人体外周血淋巴细胞SCE观察结果均为阴性。更多还原

【Abstract】 Toxicological data of Tricyclazole found in this study were as follows: Acute oral LD50:female rat,619 mg/kg;male rat,369 mg/kg;mice (both male and female),1260 mg/kg. Acute dermal LD50:rat,>2000 mg/kg.Accumulative Index K>5.0. No effect level after 90—day feeding,female rat,200 ppm,male rat,500 ppm.No teratogenic effect in rat. Mutagenicitv by Ames Test;micronu-cleus test;assessment of DNA—repairsynthesis and frequencies of SCEs inhuman peripheral blood lymphocytewere all negative.更多还原