【摘要】 <正> 食管癌的治疗,目前仍以手术和放疗为主,单纯化疗效果尚不满意。但有不少患者不适宜手术或放疗,化疗可试用于这类病人。近年来,许多研究表明热疗可以增加放疗和某些化疗药物的作用,并有食管腔内微波热疗合并放疗的临床报告。食管腔内微波热疗合并化疗治疗食管癌,作者首先试用于临床,并取得了较好疗效。在此基础上,我们进一步作了这项工作,报道如下。更多还原

【Abstract】 Thirty-two patients with esophageal cancer were treated with combination of chemotherapy and intralumenal hyperthermia from .August 1934 to June 1985. The chemotherapeautic agents were used in two combinations. PYM (Bleomycin A5) + DDP + CTX, or PYM + DDP. The patients were divided (DDP 0.5 to ,0.95mg/kg/session and 1.0 to 2.0 mg/kg/session) into high and low dose groups. Dose of PYM was 20 mg/kg/session. CTX (0.4 to 0.6gm/se.ssion) was given only to 14 out of 21 patients in the high dose group. The mean superfacial temperatures in the normal esophagus and tumor were 43℃ to 44℃ and 45℃ to 50℃. Hyperthemia and chemotherapy were given simutaneously once a week for 6 to 8 sessions. Response rates of high and low dose groups were 81% (17/21) and 36.4% (4/11) , respectively. CR .(complete response) rate of the high dose group was 38.1%( 8/21) but no CR was observed in the low dose group.更多还原