【摘要】 研究了当机体受到不同放射性活度的¹⁴⁷Pm内污染时体内滞留过程对骨髓细胞姐妹染色单体互换和PCE微核形成率的诱发效应,以及¹⁴⁷Pm沉积在近产期母体胎内诱发胎肝、脾细胞的染色体畸变效应。研究发现,体内摄入不同放射性活度¹⁴⁷Pm后,都是选择性沉积于骨和肝组织中,且随着摄入¹⁴⁷Pm放射性活度的增加,在骨和肝组织中的优势滞留比例亦呈显著升高。观察到受¹⁴⁷Pm内污染时,可诱发骨髓细胞SCE和PCE微核率明显升高,且骨髓PCE微核率的增升与骨组织的累积吸收剂量呈正相关。在母体胎内由于有胎盘障壁的存在,¹⁴⁷Pm的沉积较低。发现胎肝细胞的染色体畸变率明显高于胎脾细胞。在这二种胎内细胞的畸变类型是相一致的,主要为染色单体型畸变的染色单体断裂。并可在一个细胞中观察到有多个的畸变发生。更多还原

【Abstract】 Study of accumulation peculiarity of l47Pm showed that I.V. different doses of 147Pm were the same selectively localized in skeleton and liver. Retention of l47Pm in skeleton and liver was elevated when the radioactive doses of 147Pm were enlarged. At the same time absorption does of 147Pm radiation was heightened. The ability of 147Pm to induce sister chromatid exchanges (SCEs) has been investigated by IdU labelling methods. A statistically significant elevation of SCEs was observed after 147Pm intake. The number of SCEs per cell in bone marrow cells was always higher in mice when the animals were maintained on the doses of 37 Bq/g. The injurious effects of 147Pm, using PCE’s micronucleus rates in bone marrow cells were observed. The results showed that the lower limit of injected activity effecting marked rise of rates was 185Bq/g. While peak value appeared to 1.34% at 24 h after intake of 147Pm 1.85X 105Bq/g. I47Pm was dominantly deposited on maternal liver. Deposition of 147Pm in maternal spleen was about quandrantal of the maternal liver. In view of the placental barrier uptake of 147Pm by fetal liver or spleen was depressed. Studies indicated that maternal contamination of 117Pm could induced chromosome aberrations in fetal liver and spleen cells . Among the type of aberrations induced by 147Pm, chromatid breakage were predominant. The incidence of chromosome aberrations on fetal liver cells induced by 1<7Pm was higher on fetal spleen cells.更多还原