【摘要】 本文就干扰素对20例放疗后鼻咽癌（NPC）患者的ADDC作用进行了探讨。实验中,靶细胞为低分化NPC细胞株（CNE₂）,效应细胞为患者外周血淋巴细胞,靶细胞抗体为免抗CNE₂细胞抗体,用⁵1Cr释放法测定。结果表明经干扰素预孵的效应细胞比未经干扰素预孵的效应细胞的细胞毒平均增加33.5％（P<0.001）。ADCC是机体重要的抗肿瘤免疫机制之一,我们的实验进一步表明干扰素有促进ADDC的作用,提示,干扰素有可能在NPC患者的综合治疗中成为一种有效的免疫治疗药物。更多还原

【Abstract】 The effcts of a purified preparation of interferon （IFN） to augment human Antibody-Dependent Cell-mediated Cytotoaicity （ADCC） were studied by using ⁵¹Cr labelled poorly-differentiated nasopharyngeal carcinoma cell line （CNE₂） as target cells which were incubated in a 1:10,000 dilution of immune rabbit anti-target anti- body. The effector cells were obtained from 20 NPC patients who had received radio- therapy. It was shown that purified preparation of interferon increased ADCC activity of effector cells by 33.5% on average （P<0.001） over that of effector cells not treat- ed with IFN. Since the ADCC is an important mechanism for anti-tumor in vivo, the enhance- ment of human ADCC with interferon suggests that interferon may be an effec- tive preparation of immunotherapy for NPC patient.更多还原